abstract：:In rodents, chronic intermittent ethanol vapor exposure (CIE) produces alcohol dependence, alters the structure and activity of pyramidal neurons and decreases the number of oligodendroglial progenitors in the medial prefrontal cortex (mPFC). In this study, adult Wistar rats were exposed to seven weeks of CIE and were...

journal_title：Neuroscience

authors： Navarro AI,Mandyam CD

更新日期：2015-05-07 00:00:00

abstract：:Aversive experiences in early life are thought to dispose to psychopathologies such as mood or anxiety disorders. In a two-hit stress model, we assessed the effects of juvenile and/or adult stress on the 5-HT-mediated modulation of synaptic inhibition of ventral dentate gyrus granule cells. Combined but not single str...

journal_title：Neuroscience

authors： Gruber D,Gilling KE,Albrecht A,Bartsch JC,Çalışkan G,Richter-Levin G,Stork O,Heinemann U,Behr J

更新日期：2015-05-07 00:00:00

abstract：:Oxidative stress is believed to be a major factor for the onset of Parkinson's disease (PD). In this study, we have investigated oxidative status in transgenic Drosophila model of PD. Our results revealed elevated levels of reactive oxygen species (ROS) and lipid peroxidation (LPO) in A30P and A53T α-synuclein PD mode...

journal_title：Neuroscience

authors： Jahromi SR,Haddadi M,Shivanandappa T,Ramesh SR

更新日期：2015-05-07 00:00:00

abstract：:Caffeine works through a variety of complex mechanisms to exert an often bidirectional set of functional and structural neurological changes in vertebrates. We investigated the effects of chronic caffeine exposure on functional recovery of the dorsal light reflex (DLR) in hemilabyrinthectomized common goldfish, Carass...

journal_title：Neuroscience

authors： Goodson NB,Brockhoff BL,Huston JP,Spieler RE

更新日期：2015-04-30 00:00:00

abstract：:Migration of postmitotic neurons in the developing cortex along radial glial fiber is essential for the formation of cortical layers. Several neurological diseases are caused by defects in neuronal migration, underlining the importance of this process for brain function. Multiple molecules are involved in this process...

journal_title：Neuroscience

authors： Wang JT,Song LZ,Li LL,Zhang W,Chai XJ,An L,Chen SL,Frotscher M,Zhao ST

更新日期：2015-04-30 00:00:00

abstract：:The ability to selectively control the differentiation of neural stem cells (NSCs) into cholinergic neurons in vivo would be an important step toward cell replacement therapy. First, green fluorescent protein (GFP)-NSCs were induced to differentiate into cholinergic neuron-like cells (CNLs) with retinoic acid (RA) pre...

journal_title：Neuroscience

authors： Gu G,Zhang W,Li M,Ni J,Wang P

更新日期：2015-04-16 00:00:00

abstract：:Neurobiological and genetic mechanisms underlying increased intake of and preference for nutritive sugars over non-nutritive sweeteners are not fully understood. We examined the roles of subnuclei of the amygdala in the shift in preference for a nutritive sugar. Food-deprived mice alternately received caloric sucrose ...

journal_title：Neuroscience

authors： Yasoshima Y,Yoshizawa H,Shimura T,Miyamoto T

更新日期：2015-04-16 00:00:00

abstract：:Simvastatin is an HMG-CoA reductase inhibitor commonly used in the clinic to treat hypercholesterolemia. In addition, simvastatin has been shown to cross the blood-brain barrier and pleiotropic effects of simvastatin have been reported including anti-inflammatory properties, enhancement of neurite outgrowth, and memor...

journal_title：Neuroscience

authors： Métais C,Hughes B,Herron CE

更新日期：2015-04-16 00:00:00

abstract：:Healthy aging is accompanied by neurobiological changes that affect the brain's functional organization and the individual's cognitive abilities. The aim of this study was to investigate the effect of global age-related differences in the cortical white and gray matter on neural activity in three key large-scale netwo...

journal_title：Neuroscience

authors： Marstaller L,Williams M,Rich A,Savage G,Burianová H

更新日期：2015-04-02 00:00:00

abstract：:Studies demonstrated that chronic high-dose homocysteine administration induced learning and memory impairment in animals. Atractylenolide III (Aen-III), a neuroprotective constituent of Atractylodis macrocephalae Koidz, was isolated in our previous study. In this study, we investigated potential benefits of Aen-III i...

journal_title：Neuroscience

authors： Zhao H,Ji ZH,Liu C,Yu XY

更新日期：2015-04-02 00:00:00

abstract：PURPOSE:This study aimed to clarify whether ischemia-induced early growth response 1 (EGR1) influenced the outcomes of experimental stroke by regulating brain-derived neurotrophic factor (BDNF) expression. METHODS AND RESULTS:To mimic ischemia, mice were subjected to middle cerebral artery occlusion, and neurons chall...

journal_title：Neuroscience

authors： Yang L,Jiang Y,Wen Z,Xu X,Xu X,Zhu J,Xie X,Xu L,Xie Y,Liu X,Xu G

更新日期：2015-04-02 00:00:00

abstract：:The entorhinal cortex and other hippocampal and parahippocampal cortices are interconnected by a small number of GABAergic nonpyramidal neurons in addition to glutamatergic pyramidal cells. Since the cortical and basolateral amygdalar nuclei have cortex-like cell types and have robust projections to the entorhinal cor...

journal_title：Neuroscience

authors： McDonald AJ,Zaric V

更新日期：2015-04-02 00:00:00

abstract：:Fetal striatal transplantation has emerged as a new therapeutic strategy in Huntington's disease (HD). Hypoxia is one of the microenvironmental stress conditions to which fetal tissue is exposed as soon as it is isolated and transplanted into the diseased host brain. Mechanisms that support neuroblast survival and rep...

journal_title：Neuroscience

authors： Ambrosini S,Sarchielli E,Comeglio P,Porfirio B,Gallina P,Morelli A,Vannelli GB

更新日期：2015-03-19 00:00:00

abstract：:Serotonin (5-HT) and norepinephrine (NE) have been implicated in the mediation of endogenous analgesic mechanisms via the descending inhibitory pain pathway in the brain, and dysfunction in both the 5-HT and NE systems has been suggested as an etiology of fibromyalgia (FM). Given that 5-HT reuptake inhibition in the b...

journal_title：Neuroscience

authors： Murai N,Fushiki H,Honda S,Murakami Y,Iwashita A,Irie M,Tamura S,Nagakura Y,Aoki T

更新日期：2015-03-19 00:00:00

abstract：:Necrostatin-1 (Nec-1) is an inhibitor of necroptosis, playing an important role in inhibition of pathological death in the central nervous system (CNS). Our earlier study suggests that Nec-1 protects the injured spinal cord. In this study, we found that Nec-1 reduces the elevated Ca(2+) concentration in mitochondria p...

journal_title：Neuroscience

authors： Wang Y,Wang J,Yang H,Zhou J,Feng X,Wang H,Tao Y

更新日期：2015-03-19 00:00:00

abstract：:Early degeneration of pedunculopontine nucleus (PPN) is considered part of changes that characterize premotor stages of Parkinson's disease (PD). In this paper, the effects of unilateral neurotoxic lesion of the PPN in motor execution and in the development of oxidative stress events in striatal and nigral tissues in ...

journal_title：Neuroscience

authors： Jimenez-Martin J,Blanco-Lezcano L,González-Fraguela ME,Díaz-Hung ML,Serrano-Sánchez T,Almenares JL,Francis-Turner L

更新日期：2015-03-19 00:00:00

abstract：:Our working hypothesis is that brain neurotrophins and brain Na(+),K(+)-ATPase may be strongly associated with the occurrence of depression in animals subjected to chronic unpredictable mild stress (CUMS). Still, we believe that chrysin, a natural and bioactive flavonoid found in honey and some plants, can provide sat...

journal_title：Neuroscience

authors： Filho CB,Jesse CR,Donato F,Giacomeli R,Del Fabbro L,da Silva Antunes M,de Gomes MG,Goes AT,Boeira SP,Prigol M,Souza LC

更新日期：2015-03-19 00:00:00

abstract：:Apart from therapeutic discovery, the study of mild traumatic brain injury (mTBI) has been focused on two challenges: why do a majority of individuals recover with little concern, while a considerable proportion suffer with persistent and often debilitating symptomology; and, how do mild injuries significantly increas...

journal_title：Neuroscience

authors： Mychasiuk R,Hehar H,Ma I,Kolb B,Esser MJ

更新日期：2015-03-12 00:00:00

abstract：:The effect of lacosamide (LCS), a functionalized molecule with anti-convulsant properties, on ion channels was investigated, with the aid of patch clamp technology and simulation modeling. In NSC-34 neuronal cells, LCS was found to block voltage-gated Na(+) current (INa) in a frequency- and concentration-dependent man...

journal_title：Neuroscience

authors： Huang CW,Hung TY,Wu SN

更新日期：2015-02-26 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) are neurodegenerative diseases that overlap clinically, genetically, and pathologically. Dysregulation of fused in sarcoma (FUS) has been hypothesized to cause ALS and FTLD in gain-of-function and/or loss-of-function manners. However, the...

journal_title：Neuroscience

authors： Suzuki H,Matsuoka M

更新日期：2015-02-26 00:00:00

abstract：:The development and maintenance of cocaine addiction depend heavily on learned reward-environment associations that can induce drug-seeking behavior and relapse. Understanding the mechanisms underlying these cue-induced conditioned responses is important for relapse prevention. To test whether intracellular responses ...

journal_title：Neuroscience

authors： Nygard SK,Klambatsen A,Balouch B,Quinones-Jenab V,Jenab S

更新日期：2015-02-26 00:00:00

abstract：:The present research explored the cortical correlates of emotional memories in response to words and pictures. Subjects' performance (Accuracy Index, AI; response times, RTs; RTs/AI) was considered when a repetitive Transcranial Magnetic Stimulation (rTMS) was applied on the left dorsolateral prefrontal cortex (LDLPFC...

journal_title：Neuroscience

authors： Balconi M,Cobelli C

更新日期：2015-02-26 00:00:00

abstract：:Alzheimer's disease (AD) increases the risk for late-onset seizures and neuronal network abnormalities. An elevated co-occurrence of AD and seizures has been established in the more prevalent sporadic form of AD. Recent evidence suggests that nonconvulsive network abnormalities, including seizures and other electroenc...

journal_title：Neuroscience

authors： Born HA

更新日期：2015-02-12 00:00:00

abstract：:The aim of this study was to examine how feedback, or its absence, affects children with Developmental Coordination Disorder (DCD) during a visuo-manual tracking task. This cross-sectional study included 40 children with DCD and 40 typically developing (TD) children between 6 and 10 years old. Participants were requir...

journal_title：Neuroscience

authors： Ferguson GD,Duysens J,Smits-Engelsman BC

更新日期：2015-02-12 00:00:00

abstract：:Inflammation is an important event in ischemic injury. These immune responses begin with the expression of pro-inflammatory genes modulating transcription factors, such as nuclear factor-κB (NF-κB), activator protein-1 (AP-1), and signal transducers and activator of transcription-1 (STAT-1). The 70-kDa heat shock prot...

journal_title：Neuroscience

authors： Kim JY,Yenari MA,Lee JE

更新日期：2015-02-12 00:00:00

abstract：:Chronic stress, the administration of glucocorticoids and the prolonged activation of glucocorticoid receptors (GRs) are reported to induce affective changes in humans and rodents that resemble a depressive state. However, data concerning the behavioral and molecular effects of the selective activation of specific GRs...

journal_title：Neuroscience

authors： Skupio U,Tertil M,Sikora M,Golda S,Wawrzczak-Bargiela A,Przewlocki R

更新日期：2015-02-12 00:00:00

abstract：:Oxidative stress is central to the pathology of several neurodegenerative diseases, including Parkinson's disease (PD), and therapeutics designed to enhance antioxidant potential could have clinical value. In this study, we investigated whether dimethyl fumarate (DMF) has therapeutic effects in cellular and animal mod...

journal_title：Neuroscience

authors： Jing X,Shi H,Zhang C,Ren M,Han M,Wei X,Zhang X,Lou H

更新日期：2015-02-12 00:00:00

abstract：:Polycytosine-binding proteins (PCBPs) are RNA-binding proteins that participate in post-transcriptional control pathways. Among the diverse functions of these proteins is the interaction with a 27 nucleotide pyrimidine-rich domain within the 3'UTR of tyrosine hydroxylase (TH) mRNA. Mutations to this domain result in d...

journal_title：Neuroscience

authors： Boschi NM,Takeuchi K,Sterling C,Tank AW

更新日期：2015-02-12 00:00:00

abstract：:Diabetic peripheral neuropathy is a common complication of diabetes mellitus, and a significant proportion of individuals suffer debilitating pain that significantly affects their quality of life. Unfortunately, symptomatic treatment options have limited efficacy, and often carry significant risk of systemic adverse e...

journal_title：Neuroscience

authors： Katz NK,Ryals JM,Wright DE

更新日期：2015-01-29 00:00:00

abstract：:The dopamine D1 and D2 receptors form the D1-D2 receptor heteromer in a subset of neurons and couple to the Gq protein to regulate intracellular calcium signaling. In the present study the effect of D1-D2 heteromer activation and disruption on neuronal activation in the rat brain was mapped. This was accomplished usin...

journal_title：Neuroscience

authors： Perreault ML,Shen MY,Fan T,George SR

更新日期：2015-01-29 00:00:00

abstract：:The zebrafish olfactory system is a valuable model for examining neural regeneration after damage due to the remarkable plasticity of this sensory system and of fish species. We applied detergent to the olfactory organ and examined the effects on both morphology and function of the olfactory system in adult zebrafish....

journal_title：Neuroscience

authors： White EJ,Kounelis SK,Byrd-Jacobs CA

更新日期：2015-01-22 00:00:00

abstract：:In mice, the compact hippocampal primordium is formed during the prenatal stage by early-generated neurons that migrate from the lateral ventricular zone. However, despite much being understood about the formation of the hippocampus, the molecular mechanisms that maintain the morphology of the hippocampal primordium a...

journal_title：Neuroscience

authors： Wang HT,Zeng L,Chen Q,Zhang X,Liu JW,Lu TJ,Xiong ZQ,Zheng J,Hu ZL

更新日期：2015-01-22 00:00:00

abstract：:Eider duck (Somateria mollissima) cerebellar neurons are highly tolerant toward hypoxia in vitro, which in part is due to a hypoxia-induced depression of their spontaneous activity. We have studied whether this response involves ATP-sensitive potassium (KATP) channels, which are known to be involved in the hypoxic/isc...

journal_title：Neuroscience

authors： Geiseler SJ,Ludvigsen S,Folkow LP

更新日期：2015-01-22 00:00:00

abstract：:Acetylcholine (ACh) is well known to induce persistent γ-oscillations in the hippocampus when applied together with physostigmine, an inhibitor of the ACh degrading enzyme acetylcholinesterase (AChE). Here we report that physostigmine alone can also dose-dependently induce γ-oscillations in rat hippocampal slices. We ...

journal_title：Neuroscience

authors： Hollnagel JO,Ul Haq R,Behrens CJ,Maslarova A,Mody I,Heinemann U

更新日期：2015-01-22 00:00:00

abstract：:Nerve injuries cause pain, paralysis and numbness that can lead to major disability, and newborns often sustain nerve injuries during delivery that result in lifelong impairment. Without a pharmacologic agent to enhance functional recovery from these injuries, clinicians rely solely on surgery and rehabilitation to tr...

journal_title：Neuroscience

authors： Kemp SWP,Szynkaruk M,Stanoulis KN,Wood MD,Liu EH,Willand MP,Morlock L,Naidoo J,Williams NS,Ready JM,Mangano TJ,Beggs S,Salter MW,Gordon T,Pieper AA,Borschel GH

更新日期：2015-01-22 00:00:00

abstract：:Dorsal vagal complex (DVC) AMPK regulation of food intake in the estradiol-treated ovariectomized (OVX) female rat is energy state-dependent. Here, RT-PCR array technology was used to identify estradiol-sensitive AMPK-regulated DVC signal transduction pathways that exhibit differential reactivity to sensor activation ...

journal_title：Neuroscience

authors： Ibrahim BA,Alenazi FSH,Briski KP

更新日期：2015-01-22 00:00:00

abstract：:The neuropeptide substance P is an excitatory neurotransmitter produced by various cells including neurons and microglia that is involved in regulating inflammation and cerebral blood flow--functions that affect sleep and slow-wave activity (SWA). Substance P is the major ligand for the neurokinin-1 receptor (NK-1R), ...

journal_title：Neuroscience

authors： Zielinski MR,Karpova SA,Yang X,Gerashchenko D

更新日期：2015-01-22 00:00:00

abstract：:Administration of kainic acid induces acute seizures that result in the loss of neurons, gliosis and reorganization of mossy fiber pathways in the hippocampus resembling those observed in human temporal lobe epilepsy. Although these structural changes have been well characterized, the mechanisms underlying the degener...

journal_title：Neuroscience

authors： Banerjee M,Sasse VA,Wang Y,Maulik M,Kar S

更新日期：2015-01-22 00:00:00

abstract：:Non-invasive criteria determining the progress of brain healing are especially important in aging, providing a case-specific therapeutic strategy in populations with dysregulated neurorepair mechanisms. We hypothesized that temporal evolution of magnetic resonance imaging (MRI) of T2 tissue relaxation values correlate...

journal_title：Neuroscience

authors： Titova EM,Ghosh N,Valadez ZG,Zhang JH,Bellinger DL,Obenaus A

更新日期：2014-12-26 00:00:00

abstract：:Nogo-A interaction with its different receptors (Nogo receptor 1 (NgR1), S1P receptor 2 (S1PR2), paired immunoglobulin-like receptor B (PirB)) restricts plasticity and growth-dependent processes leading, via the activation of different signaling pathway to the stabilization of the neuronal networks (either development...

journal_title：Neuroscience

authors： Zagrebelsky M,Korte M

更新日期：2014-12-26 00:00:00